Xencor Presents Preclinical Data on XmAb®24306, Introduces XmAb® IL15 Bispecific Platform at American Association for Cancer Research (AACR) 2018 Annual Meeting
Key findings from the study presented today at the
- Fusing IL15/IL15Rα with
Xencor's highly stable heterodimer Fc platform and Xtend Fc domain creates a long-acting CD122 agonist, without targeting CD25 - Potency reduction of the complex promotes improved exposure and sustained pharmacodynamics
- Preserves native CD122/CD132 signaling despite potency reduction
- Marked and sustained peripheral NK and T cell expansion at well-tolerated doses
"The plug and play nature of our XmAb technology provides tremendous opportunity to build a suite of tumor microenvironment activators with tunable potency and sustained activity, which have the potential for improved performance over current approaches," said
XmAb24306 is the first of a suite of tumor microenvironment activators using the IL15 bispecific platform. Additional IL15 bispecific candidates, which target specific sub-populations of T cells, in preclinical development include:
- A PD1 targeted IL15/IL15Rα (PD1 x IL15) candidate to promote selective expansion and activation of exhausted T cells
- Additional targeted IL15/IL15Rα candidates
About XmAb® IL15 Bispecific Platform
About
Xencor is a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of autoimmune diseases, asthma and allergic diseases and cancer. Currently, 11 candidates engineered with Xencor's XmAb® technology are in clinical development internally and with partners. Xencor's internal programs include: XmAb®5871 in Phase 2 development for the treatment of IgG4-Related Disease, and also for the treatment of Systemic Lupus Erythematosus; XmAb®7195 in Phase 1 development for the treatment of asthma and allergic diseases; XmAb®14045 in Phase 1 development for acute myeloid leukemia; XmAb®13676 in Phase 1 development for B-cell malignancies; XmAb®18087 in Phase 1 development for the treatment of neuroendocrine tumors and gastrointestinal stromal tumors; and XmAb®20717, XmAb®22841, XmAb®23104 and XmAb®24306 in pre-clinical development for the treatment of multiple cancers. Xencor's XmAb antibody engineering technology enables small changes to the structure of monoclonal antibodies resulting in new mechanisms of therapeutic action. Xencor partners include Novartis, Amgen, MorphoSys, CSL/Janssen, Alexion and Boehringer Ingelheim. For more information, please visit www.xencor.com.
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SOURCE
Investor, John Kuch, Vice President Finance, Xencor, Tel: 626-737-8013, jkuch@xencor.com; or Corporate Communications, Jason I. Spark, Canale Communications for Xencor, Tel: 619-849-6005, jason@canalecomm.com