0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Marketable Debt and Equity Securities link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Sale of Additional Common Stock link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Collaboration and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Sales of Future Royalties link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - 401(k) Plan link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Polices) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Marketable Debt and Equity Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Collaboration and Licensing Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Sales of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Summary of Significant Accounting Policies - Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Summary of Significant Accounting Policies - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Summary of Significant Accounting Policies - Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Summary of Significant Accounting Policies - Marketable Debt and Equity Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies - Concentrations of Risk (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Significant Accounting Policies - Fair Value of Financial Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Patents, Licenses, and Other Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of Significant Accounting Policies - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Summary of Significant Accounting Policies - Stock-Based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Summary of Significant Accounting Policies - Net Income (Loss) Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Summary of Significant Accounting Policies - Segments (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Marketable Debt and Equity Securities - Schedule of marketable securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Marketable Debt and Equity Securities - Maturities (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Marketable Debt and Equity Securities - Unrealized Losses (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Marketable Debt and Equity Securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Marketable Debt and Equity Securities - Equity Securities with Readily Determinable Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Marketable Debt and Equity Securities - Equity Securities without Readily Determinable Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Marketable Debt and Equity Securities - Net Gains and Losses (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Sale of Additional Common Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Property and Equipment - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Income Taxes - Schedule of Components on Income Tax Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Income Taxes - Reconciliation to effective income tax (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Income Taxes - Deferred tax assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Income Taxes - Unrecognized Tax Benefit (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Stock-Based Compensation - Employee Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Stock-Based Compensation - Stock Options Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Stock-Based Compensation - Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Stock-Based Compensation - FV of Employee Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Stock-Based Compensation - Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Leases - Undiscounted Cash Flows (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Leases - Undiscounted Cash Flows (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Leases - Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Collaboration and Licensing Agreements - Alexion Pharmaceutical, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Collaboration and Licensing Agreements - Amgen Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Collaboration and Licensing Agreements - Astellas Pharma Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Collaboration and Licensing Agreements - Genentech, Inc., and F. Hoffmann-La Roche Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Collaboration and Licensing Agreements - Gilead Sciences, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Collaboration and Licensing Agreements - Janssen Biotech, Inc., a Johnson & Johnson company (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Collaboration and Licensing Agreements - MorphoSys AG/Incyte Corporation (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Collaboration and Licensing Agreements - Novartis Institute for Biomedical Research, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Collaboration and Licensing Agreements - Omeros Corporation (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Collaboration and Licensing Agreements - Shanghai Mabgeek Biotech Co., Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Collaboration and Licensing Agreements - Vega Therapeutics (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Collaboration and Licensing Agreements - Vir Biotechnology, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Collaboration and Licensing Agreements - Zenas BioPharma, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Collaboration and Licensing Agreements - Third-Party Licensee (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Collaboration and Licensing Agreements - Technology License Agreement and Services Agreement with Gale Therapeutics Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Collaboration and Licensing Agreements - Revenue Recognition (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Collaboration and Licensing Agreements - Remaining Performance Obligations and Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Sales of Future Royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955574 - Disclosure - Sales of Future Royalties - Debt of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 9955575 - Disclosure - 401(k) Plan (Details) link:presentationLink link:calculationLink link:definitionLink