0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Organization and Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Collaboration and Licensing Agreements link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Fair Value Measurement link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Balance Sheet Accounts link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Liabilities Related to the Sales of Future Royalties link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Employee Benefit Plans link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Organization and Summary of Significant Accounting Policies (Polices) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Organization and Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Collaboration and Licensing Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Fair Value Measurement (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Balance Sheet Accounts (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Liabilities Related to the Sales of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Stock Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Organization and Summary of Significant Accounting Policies - Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Organization and Summary of Significant Accounting Policies - Cash, Cash Equivalents and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Organization and Summary of Significant Accounting Policies - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Organization and Summary of Significant Accounting Policies - Concentrations of Risk (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Organization and Summary of Significant Accounting Policies - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Organization and Summary of Significant Accounting Policies - Patents, Licenses, and Other Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Organization and Summary of Significant Accounting Policies - Segment Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Collaboration and Licensing Agreements - Revenue by Licenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Collaboration and Licensing Agreements - Disaggregation of Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Collaboration and Licensing Agreements - Receivables and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Collaboration and Licensing Agreements - Alexion Pharmaceutical, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Collaboration and Licensing Agreements - Amgen Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Collaboration and Licensing Agreements - Gilead Sciences, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Collaboration and Licensing Agreements - Janssen Biotech, Inc., a Johnson & Johnson company (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Collaboration and Licensing Agreements - Incyte Corporation (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Collaboration and Licensing Agreements - Hunan Mabgeek Biotech Co., Ltd. fka Shanghai Mabgeek Biotech Co., Ltd. (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Collaboration and Licensing Agreements - Novartis Institute for Biomedical Research, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Collaboration and Licensing Agreements - Novo Nordisk Health Care AG (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Collaboration and Licensing Agreements - Vega Therapeutics (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Collaboration and Licensing Agreements - Vir Biotechnology, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Collaboration and Licensing Agreements - Zenas BioPharma, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Collaboration and Licensing Agreements - Third-Party License (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities - Schedule of Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities - Maturities of Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities - Equity Securities with Readily Determinable Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Cash Equivalents, Marketable Debt and Equity Securities - Net Realized and Unrealized Gains (Losses) on Marketable Equity Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Fair Value Measurement (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Balance Sheet Accounts - Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Balance Sheet Accounts - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Balance Sheet Accounts - Indefinite and Finite-Lived Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Balance Sheet Accounts - Finite-Lived Intangible Assets, Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Balance Sheet Accounts - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Liabilities Related to the Sales of Future Royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Liabilities Related to the Sales of Future Royalties - Debt of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Stockholders’ Equity - Stock by Class (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Stockholders’ Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Leases - Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Leases - Undiscounted Cash Flows (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Leases - Undiscounted Cash Flows (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Leases - Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Stock Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Stock Based Compensation - Share-Based Payment Arrangement, Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Stock Based Compensation - Employee Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Stock Based Compensation - Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Stock Based Compensation - FV of Employee Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Stock Based Compensation - Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Stock Based Compensation - FV of Employee Stock Purchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Income Taxes - Components on Income Tax Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Income Taxes - Reconciliation to effective income tax (Details) link:presentationLink link:calculationLink link:definitionLink 9955574 - Disclosure - Income Taxes - Income taxes paid (Details) link:presentationLink link:calculationLink link:definitionLink 9955575 - Disclosure - Income Taxes - Deferred tax assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955576 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955577 - Disclosure - Income Taxes - Unrecognized Tax Benefit (Details) link:presentationLink link:calculationLink link:definitionLink 9955578 - Disclosure - Employee Benefit Plans (Details) link:presentationLink link:calculationLink link:definitionLink 9955579 - Disclosure - Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955580 - Disclosure - Segment Reporting - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955581 - Disclosure - Segment Reporting - Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink